Posted by jonathanupr on December 30, 2006, at 22:45:11
In reply to Modafinil(Provigil)withDepakote(divalproex sodium), posted by Dragoon on December 29, 2006, at 12:18:56
interesting combo
I'd think there'd be some competitive action going on at the glutamate and GABA receptor sites, as Depakote (from what I've read on it, a bit rusty on Depakote, more up on other ACs such as Topomax, etc. Anyways, if Depakote acts anything like Topomax in inhibiting the release of glutamate and activating the release of GABA, then I'd think it may be contraindicative to Provigil, as Provigil does the opposite in stimulating glutamate release and inhibiting GABA release). The big question I'd have is where these 2 drugs are active within the CNS, they may act in different regions of the brain and thus may complement each other. Best thing I've come by: trying things out. Good luck.
poster:jonathanupr
thread:717273
URL: http://www.dr-bob.org/babble/20061224/msgs/717708.html