Posted by zeugma on November 10, 2006, at 11:07:40
In reply to Re: Half-life ? » zeugma, posted by Meri-Tuuli on November 10, 2006, at 10:54:00
> Sorry to interrupt, but I have a question....
>
> >in 2D6 slow metabolizers it's 24 hrs. in rapid (or 'normal') metabolizers it's 5 hrs.
>
> How do you know which genotype you are? Well other than expensive genetic testing, I mean, what are the clinical signs (in general) if you can tell?>>the main way to know is to get your plasma levels tested while taking a TCA. This was standard practice here in the U.S. for many years and I have had my nortriptyline levels taken several times.
But so many drugs affect this. For instance Paxil will convert you from a 'rapid metabolizer' to a 'slow metabolizer.'
It has been known even before the relavant enzymes were identified that TCA's were dependent on plasma levels. For other psych drugs, relationships are less clear.
But I'd guess, for example, that reboxetine's efficacy would be lessened by provigil.
-z
>
> Kind regards
>
> Meri
>
poster:zeugma
thread:702062
URL: http://www.dr-bob.org/babble/20061110/msgs/702267.html