Posted by SLS on July 23, 2006, at 12:33:22
In reply to Re: what is my problem » saturn, posted by linkadge on July 22, 2006, at 19:45:02
> Strange.
>
> There are a few different varients of the serotonin transporter gene. Each code for a different level of baseline activity. People with the SS varient (which seems to code for a lower baseline uptake of serotonin) seem to experience more side effects during SSRI treatment.Just musing...
I would guess that the postsynaptic membrane would have a greater density of receptors at baseline in the SS condition. This would explain the more pronounced serotonergic side effects. If they do not downregulate in the presence of an SRI and the attendant increased concentration of serotonin, the side-effects would persist and there would be a reduced chance of obtaining a robust antidepressant response as the synaptic dynamics are not restructured to enhance transmission efficiency. Again, the resistence against downregulation might be an artifact of the lack of appropriate synaptic serotonin during critical phases of development. Again, pindolol might help.
- Scott
poster:SLS
thread:669157
URL: http://www.dr-bob.org/babble/20060717/msgs/669685.html