Posted by saturn on June 25, 2006, at 19:07:24
It seems that Provigil is actually *not* a central alpha 1 agonist, from what I gather, though much circulating data still says so.
Does anyone know if provigil has peripheral alpha 1 agonistic actions?
Is it safe to combine a beta blocker w/ Provigil to counter any excess peripheral stimulation if provigil is an alpha one agonist (or in any instance)?
I'm wondering if this would cause excess alpha 1 stimulation. My understanding is that beta receptors cause peripheral vasodilation whereas alpha causes constriction. Blocking beta without blocking alpha--or even further stimulating the receptor can lead to excessive vasoconstriction and resulting hypertension and possibly resulting heart problems, etc...
Any thoughts? Thanks. Peace. Saturn.
poster:saturn
thread:661381
URL: http://www.dr-bob.org/babble/20060623/msgs/661381.html