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does provigil have peripheral alpha1 actions?

Posted by saturn on June 25, 2006, at 19:07:24

It seems that Provigil is actually *not* a central alpha 1 agonist, from what I gather, though much circulating data still says so.

Does anyone know if provigil has peripheral alpha 1 agonistic actions?

Is it safe to combine a beta blocker w/ Provigil to counter any excess peripheral stimulation if provigil is an alpha one agonist (or in any instance)?

I'm wondering if this would cause excess alpha 1 stimulation. My understanding is that beta receptors cause peripheral vasodilation whereas alpha causes constriction. Blocking beta without blocking alpha--or even further stimulating the receptor can lead to excessive vasoconstriction and resulting hypertension and possibly resulting heart problems, etc...

Any thoughts? Thanks. Peace. Saturn.


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URL: http://www.dr-bob.org/babble/20060623/msgs/661381.html