Posted by blueberry on May 25, 2006, at 17:01:05
In reply to Could initial response come back?, posted by addinbc on May 25, 2006, at 2:54:39
I have experienced that phenomenon myself and have seen it many times with other people. There are a good couple days, followed by worsening. This is just a theory, but this is what I think happens...
At first the increased norepinephrine is sensed by the receiving receptors and it feels good. The feedback mechanism doesn't kick in right away, but after a day or two it figures out there is a lot of extra NE and it kicks in shutting down the production of any more NE release. That's when the bad mood hits. After a few more weeks, the feedback mechanism readjusts to the higher levels of NE, and everything returns to the way it was, except that now there is a lot more NE than before starting the med, and hopefully by that point the good mood returns. But since we are all different, maybe the feedback mechanism will not fully readjust and will stay in slow motion. Don't know. Just a theory.
When my mood has plummetted really bad after a few days on a med, following a couple good days, it was so bad that I could not continue.
Starting with ultralow doses and moving up in very tiny steps might help. But that takes a lot longer.
poster:blueberry
thread:648249
URL: http://www.dr-bob.org/babble/20060525/msgs/648525.html