Posted by SLS on April 21, 2006, at 16:05:46
In reply to Re: interesting- re clonazepam and 5-HT transporte, posted by linkadge on April 21, 2006, at 15:03:10
> I could be wrong, but I think that abstract is confusing since its refering to both presynaptic autoreceptors, and post synaptic 5-ht1a receptors in the forebrain as simply 5-ht1a receptors.
I am under the impression that 5-HT1a receptors in the hippocampus are primarily postsynaptic and inhibitory. Either way, it seems that these receptors are modulatory rather than excitatory.
I know this is simplistic, but it seems to me that pushing the system in one direction (SRI) or the other (tianeptine) results in the same thing. This would be a series of compensatory changes that produce a more functional balance of receptors and neurotransmitter.
- Scott
poster:SLS
thread:629584
URL: http://www.dr-bob.org/babble/20060417/msgs/635602.html