Psycho-Babble Medication | about biological treatments | Framed
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I ask because of this study...

Posted by River1924 on April 3, 2006, at 23:56:55

In reply to enbel / atanercept, posted by River1924 on April 3, 2006, at 2:21:58

http://www.dukemednews.duke.edu/news/article.php?id=9419

"Durham, N.C. –- Etanercept (trade name Enbrel), approved for treating rheumatoid arthritis, effectively reduces not only the symptoms of the disease, but also depression and fatigue in psoriasis sufferers, according to a multi-university research team that includes a scientist at Duke University Medical Center. Etanercept, an antibody that blocks tumor necrosis factor-alpha, significantly improved the symptoms and depression associated with the disorder, the researchers reported in an article published online Dec. 14, 2005 by The Lancet........"

"Notably, researchers found significant improvements on the BDI in the etanercept group in feelings of guilt, irritability, interest, appearance, work, sleep and sexual symptoms, compared with those receiving placebo. Ham-D scores for those receiving the etanercept showed improvements to insomnia, work, hypochondriasis and sexual problems when compared to the placebo group.

The etanercept group also showed lower levels of fatigue, with the improvement strongly correlated to improvements in joint and skin pain due to psoriasis, according to the researchers. Improvement in depression levels could not be correlated to improvement in those symptoms. However, the researchers point out that the study was not designed to detect the effect of etanercept on primary depression.

"While depression scores improved, we cannot be sure why," Krishnan said. "Our next step is to run this type of trial in people who have depression but not psoriasis. At this point, no one should run to their doctor and ask for this drug for depression. However, the science is very exciting to us."

The team's work is an important first look in humans at how a TNF antibody could improve secondary symptoms of depression, said Krishnan. Further research will unveil more clues to how TNF receptors work in the brain and may eventually lead to improved treatments for depression."


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