Posted by Jedi on November 29, 2005, at 21:33:01
In reply to Re: MAOI diet question - HELP! Jedi (nm), posted by sdb on November 29, 2005, at 9:30:54
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> Nardil was replaced by moclobemide which I consider as a placebo (Roche). They sell the moclobemide because Nardil is too old thus patent rights are no more protected and the phenelzine can be cheaply produced by generic chemical suppliers now. Poorly many pdocs now nothing about phenelzine and they prescribe moclobemide here, from which I have never heard a real success story.
>
> sdbHi sdb,
When I first read about Moclobemide I thought, "what a great drug". Because of the reversible affect on MAO, there would be minimal food restrictions, a less dangerous MAOI. However after several years and watching peoples responses on this board and the clinical studies, I changed my mind. For some people it may be a wonder drug, but for the treatment resistant(which is most everbody here) it just does not provide the needed results.Moclobemide is not approved by the FDA in the US, probably because of the cost and legal hurdles involved. It can cost over $250 million to get through all of the trials to have a medication approved. This is a big financial risk. There are quite a few efficacious foreign developed medications that will never be approved in the US.
Even though phenelzine is off patent, Nardil is the only brand that is available in the US. I assume this is for financial reasons also. Not such a huge market for dangerous medications, as the MDs watch their malpractice insurance go out of sight.
In my opinon, however, the irreversible MAOI-Nardil is the medication of choice for treatment resistant atypical depression and social anxiety. There are a lot of us, atypical depression is actually very typical. Take care and good luck.
Jedi
poster:Jedi
thread:576446
URL: http://www.dr-bob.org/babble/20051126/msgs/583501.html