Posted by Jedi on October 9, 2005, at 11:57:45
In reply to Re: Doctor wants me off Nardil... » Jedi, posted by Tepiaca on October 9, 2005, at 10:52:52
> He suggested TOLVON, but first he talk about CYMBALTA. I have never used this drugs.
> What do you think about them ???
First, is there any way to contact your previous doctor and get him/her to continue the Nardil script until you can find a PDOC that is not MAOI phobic?I have never used either of the meds mentioned above. I have used the SNRI venlafaxine which is similar to Cymbalta in that it affects both serotonin and norepinephrine. I had a partial response to venlafaxine but I still had a bad case of anhedonia. I think I need the dopamine and Gaba affects that you get with Nardil.
Duloxetine and Venlafaxine-XR in the Treatment of Major Depressive Disorder: A Meta-Analysis of Randomized Clinical Trials (November).
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16189284&query_hl=2I've read that mianserin(Tolvon) is similar to mirtazapine and can cause fairly severe sedation when first taken. I really know very little about this medication.
JediPS "Mianserin is a tetracyclic antidepressant that is similar to the tricyclic anti-depressants (TCAs).
When depression occurs, there may be a decreased amount of the chemicals noradrenaline and serotonin released from nerve cells in the brain. When these chemicals are released from nerve cells they act to lighten mood. When they are reabsorbed into the nerve cells, they no longer have an effect on mood.
"Mianserin works by preventing the re-absorption of noradrenaline back into the nerve cells. It may also act to block certain receptors in the brain that bind released serotonin. This helps enhance and prolong the mood-lightening effect of any released noradrenaline and serotonin, thereby helping relieve depression.
The full benefits of treatment with mianserin may not appear for two to four weeks.
Side effects:
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Joint pain (arthralgia)
Seizures (convulsions)
Decreased production of blood cells by the bone marrow (bone marrow suppression)
Dizziness
Excessive fluid retention in the body tissues, resulting in swelling (oedema)
A drop in blood pressure that occurs when going from lying down to sitting or standing, which results in dizziness and lightheadedness (postural hypotension)
A mild degree of mania (hypomania)
Mild yellowing of the skin and eyes (mild jaundice)
Breast pain and tenderness or male breast enlargement
Disturbances of liver function
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
Mianserin should not be taken with a monoamine oxidase inhibitor (MAOI) antidepressant. Treatment with mianserin should not be started until 2 weeks after stopping a MAOI.
Mianserin may increase the anti-clotting effect of coumarin anticoagulants such as warfarin. The manufacturer recommends regular blood tests to monitor blood clotting ability.
Mianserin blood levels may be decreased by phenytoin.
Mianserin may increase the sedating effects of alcohol."
poster:Jedi
thread:564793
URL: http://www.dr-bob.org/babble/20051003/msgs/564873.html