Posted by Elroy on June 29, 2005, at 18:47:03
In reply to Anti-Cortisol Therapy: Remeron ... or Zyprexa?? » Elroy, posted by cache-monkey on June 29, 2005, at 0:34:17
Interesting article.
My primary reason for taking Remeron is for its cortisol-lowering effect. It was actually prescribed by my PCP / GP for that purpose rather than my psych doc (though she did agree with the prescription).
My primary problem (as far as mental / emotional disorder) consists of anxiety apparently induced by highly elevated cortisol which appears to have been induced by a malfunction of the HPA Axis. This has been born out by a daignosis of Pseudo Cushings by attending endo. Anyway, that led to the PCP's belief that possibly using Remeron will bring the cortisol levels down and permit the HPA Axis to "re-set". (I do have some degree of depression, but it came along over the last few months - this all just started over the last couple of years - and is a depression based on what's going on with my medical condtion versus a general depression)
Are you aware of any studies or trials using Zyprexa that showed a cortisol-lowering effect?
Thanks.
Elroy
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X> Hi Elroy,
>
> I've been reading your posts on cortisol with great interest. Thanks for posting all the useful information.
>
> In some of the links you posted on Remeron as effective cortisol therapy, the authors attribute this to its 5-HT2 blockade. Remeron is known for its 5-HT2a antagonism, but less well known is that it also blocks the 5-HT2c receptors almost as hard [1]. This is a lot like Zyprexa at low doses, although with Z you also get the D-2 antagonsim. So, Zyprexa might present a reasonable altertnative in reducing cortisol levels for people who can't get over the anti-histaminic effects of Remeron.
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> I only have personal experience with Zyprexa. So far, it seems to have mitigated a fair chunk of my free-floating anxiety that was the residual from a prolonged period of stress.
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> Just a thought,
> cache-monkey
>
> [1] http://www.preskorn.com/columns/0003.html
>
poster:Elroy
thread:515432
URL: http://www.dr-bob.org/babble/20050627/msgs/521201.html