Posted by willyee on March 29, 2005, at 15:28:51
In reply to Parnate vs Nardil, posted by ixus on March 27, 2005, at 7:15:47
I dont think youll be able to compare them now,mainly ecause most nardil users,veterans who used it for years are not responding to it due to the formulation change.
There is an entire group devoted on this matter,trying to get back the old nardil,as for the new one it seems almost every user (few hundred) on the group agrees the new nardil is totaly ineffective,in fact most of them have gotten off to go on parnate or something else until and if they manage to correct the formulation process.
The issue of amhpetmine with parnate is debated,either way its not very much and no one believes its the drugs therputic action.It has a higher affinity for dopamine which may be why some respond very well.
Nardil has a metabolite that increases gaba,however remeber gaba isnt the key for everyone and is somtimes overated.Pure gaba increase like with neurontion etc can worsen some peoples depression.Benzos do a lot more than increase gaba,and nardil more likly wont replace the need for a benzo if u use one.
I personaly wanted to give nardil a run after exhausting parnates benifits,however i had the new pill and it did not work,worsened my symptoms,i was relieved to see hundreds of veterns of the drug feel the same way,knowing i havent really tried it,and knowing it MIGHT come back gives me a option in the future,options are a depressives best friend!
Main things i took in from the old nardil and parnate were..
parnate; Initial fast acting,for some like myself with in the first 48 hrs,this could be a plus for someone in really really bad shape who needs something to work yesterday.Parnate is also stimulating at first,in a book i have it is talked about as being a smart drug along with deprenyl.This can possably help some with minor adhd.Parnate also is unlikely to cause any erectile disturbances,in fact it can make you want it more.Last parnate seems to be forgiving for most when augmented.
Negative parnate; Just as its fast acting,it for me seems to clear just as fast.I actualy feel sometimes like a morning dose is comptly gone and feel no effect what so ever,most people agree parnate is most effetive with contoius doses through the day.This is annoying.
Parnate also is horrid on sleep,and only a lucky few will not devolp bad insomnia.Parnate also is notrious for poop out,leaving u with a fading memory of how great it once worked.Parnate is also not nice on morning anxiety the next day.I can think of a lot more but i think this is enough.
Nardil postive: The old nardil was touted as a gold standerd.Unlike parnate it took a while to build up in your system,however unlike parnate is dident seem to quit as fast and require such contnoius erract dosing.It could be more maintinace dosed.Nardil prob due to its gaba effects did seem to have more social benifits to it than parnate,parnate doesent really make you feel the urge to interact with others,just allows u too,nardil supposedly did encrouage it.
Nardil negative: Nardil is active longer,so its not as forgiving with foods or augmentation as parnate is.Nardil seemed to carry weight gain as well.Also for some if nardil dident work it actualy worsened the depression.
I would like to try nardil myself and wait for the word on the old formualtion comming back.Parnate is just requiring too much work now and not providing nearly the results it once did.
P.S Liquid deprenyl with klonopin seem to have a synergy and provided relief for me at a time.Deprenyl alone should hardly ever be used unless you want to be a maniac shaking hornball.With klonopin however,it was very relaxing.Also i forgot to mention,the fact that parnate needs to be dosed a few times,and seems to clear a lot,actualy showed true i rember reading in a few places that they believe parnate is not a ir-reversable maoi,but more so a revarsable one.This varies however at doseage.It would make sense to me as it feels that way.
Nardil by all means is a ir-reversable one.In the long run id rather have one like nardil where i dont have to keep taking it,i know moclicmide is also reversable and that too needs coninoust dosing through the day.
poster:willyee
thread:476149
URL: http://www.dr-bob.org/babble/20050326/msgs/477285.html