Posted by jasmineneroli on February 5, 2005, at 18:11:49
In reply to Re: short or long acting benzos produce more tolerance, posted by med_empowered on February 5, 2005, at 17:19:13
I think it has more to do with the action the benzo's have, and the purpose for taking them.
For instance, there might be more of a tolerance issue to the sedating benzo's, OR benzo's taken in higher doses for sleep. For some reason, people seem to need more and more to achieve the same sedating quality. Sedation is the first side effect to go away when starting on a benzo, in my experience. I just think it's a temporary effect, until the body adjusts. I'm wildly guessing that this mechanism is not so much to do with GABA as something else!
Also, Xanax and Ativan, seem to give an uplifting, or slight "kick" effect, as well as an anxiolytic effect. People then get to enjoy this added bonus, but it wears off, as they adjust to it, like the sedation SE. So, people "want" a higher dose to maintain the bit of euphoria. This may be more a "psychological" tolerance, than a physiological one, too. Again, I think there's something else involved in these benzo's effect, than just GABA. Anyone know??
It seems to me, that those same people are still getting an anxiolytic effect from the drug. Just not the "lift".Whereas, Klonopin, is not particularly sedating in the average dose range (especially after the first week), nor does it have the "kick" of Xanax. I know that it has a weak serotonergic effect, in addition to GABA. This may account for it's different qualities, and the fact that a lot of people do not seem to build up a tolerance as much to Klon. as to some other benzo's.
Just my thoughts.
Jas
poster:jasmineneroli
thread:453705
URL: http://www.dr-bob.org/babble/20050202/msgs/453717.html