Posted by Ktemene on January 14, 2005, at 10:23:20
In reply to Re: My friend w/ PD had hypertensive crisis- seleg » Ktemene, posted by ed_uk on January 13, 2005, at 6:16:01
> >I was once under the impression that, at 5mg/day selegiline, one should have no problem taking an SSRI concurrently, and you would still see complete or near-complete inhibition of MAO-B. I've revised my thinking, especially since I've been experimenting with small-molecule drugs a lot a work, and seen some of the variation that can occur in dosing, even among inbred animals.
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> Hi Ktemene,
>
> I think that most people would be fine on 5mg selegiline + an SSRI, but as you say, it would be very difficult to predict who would react badly and develop the SS. BTW, what is your job?
>
> Regards,
> Ed.Hi Ed,
I think you are right about the combination of 5mg Selegiline + SSRI, and I have been taking 5mg Selegiline with other meds (although not any SSRI's) without any problem. The job you are asking about is Adam's. I was just copying an old post of his. Adam was part of the Selegiline patch study (now Emsam) in 1999, and had a very positive reaction. After the study was over he started taking Selegiline orally. His posts are terrific, both for the information that he passes on and for the sensitivity of his observations about depression as a human being. It is worth searching the archives for his posts.
Ktemene
poster:Ktemene
thread:440536
URL: http://www.dr-bob.org/babble/20050113/msgs/442096.html