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Re: Ok, someone tell me something about Risperdal » mmcconathy

Posted by King Vultan on January 5, 2005, at 8:07:23

In reply to Ok, someone tell me something about Risperdal, posted by mmcconathy on January 4, 2005, at 12:55:59

> I'm losing my mind, and i heard this is an effective form of Thorazine without the side-effects.
>
> Will there be Zombie side effects, "no-emotion", feel dead, yea no-brain synrome.
>
> Now Zyprexa? i want to know about this too, does this cause zombie side effects?
>
> Is it effective comepared to Risperdal?
>
> THnaks you
>
> Do you think im insane>?
>
> matt

I'm taking Risperdal at a very low dosage (0.25 mg/day, probably eventually going to 0.50 mg/day) to augment my Parnate and counteract some of the negative effects from the MAOI increasing serotonin transmission. At this dosage, I have zero side effects, and it is already lowering my agitation levels subtly but definitely.

Risperdal begins to have antipsychotic effects on positive symptoms probably up in the range of 3-4 mg/day, based on what I've read. It is probably the least atypical of the atypical APs at antipsychotic dosages because it increases prolactin levels about as much as the old style antipsychotics, and it seems to have an unusually high affinity for the dopamine D2 receptor. The latter tends to result in more EPSEs than other atypicals and may be responsible for explaining the excessive zombification some people have reported.

At lower levels of perhaps 0.5-1.0 mg/day, Risperdal is highly selective for the serotonin-2A receptor, with relatively low dopamine D2 receptor occupancy, which is what led to my interest in it. Risperdal is not a terrible drug, but as I indicated, it has some characteristics that are more like conventional antipsychotics than atypicals. I do not believe it has any significant tendency to cause TD, though, even at normal antipsychotic dosages.

Todd


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poster:King Vultan thread:437659
URL: http://www.dr-bob.org/babble/20050103/msgs/438056.html