Posted by ed_uk on December 31, 2004, at 19:52:38
A question for OCD sufferers.....
I suffer from OCD. Has anyone with OCD taken a stimulant such as Adderall, Dexedrine or Ritalin. If so, did it have any effect on your OCD? Better? Worse? No effect?
A question for all stimulant users, whatever their diagnosis.....
Does the stim motivate you to concentrate on things which you don't normally enjoy? ....or do you just end up doing MORE of the things which you do enjoy?
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Interesting reports.........
J Clin Psychopharmacol. 1991 Aug;11(4):237-41.
Acute psychostimulant challenge in primary obsessive-compulsive disorder.
Joffe RT, Swinson RP, Levitt AJ.
Department of Psychiatry, Toronto General Hospital, Ontario, Canada.
The effects of acute oral administration of methylphenidate 40 mg versus dextroamphetamine 30 mg versus matched placebo were compared in 11 patients with primary obsessive-compulsive disorder. Dextroamphetamine but not methylphenidate had a significantly greater antiobsessive-compulsive effect as measured by the Comprehensive Psychiatric Rating Scale--Obsessive-Compulsive Subscale, as compared with placebo. This effect appeared unrelated to their effect on depression although a differential effect of the two psychostimulants on anxiety was observed. Although both these stimulants affect serotonin, the differences noted between dextroamphetamine and methylphenidate suggest that catecholamines may be implicated in the pathophysiology of obsessive-compulsive disorder.
Psychopharmacology (Berl). 1983;80(3):231-5.D-amphetamine in obsessive-compulsive disorder.
Insel TR, Hamilton JA, Guttmacher LB, Murphy DL.
In a double-blind crossover study, single doses of d-amphetamine and placebo were administered to 12 patients with severe chronic obsessive-compulsive disorder (OCD). Improvement of obsessional symptoms was significant on clinical ratings and was correlated with improved performance on an attention task. Changes were also significant for self-rated measures of activation and altered reality. The behavior response to amphetamine was not statistically correlated with subsequent improvement during a 6-week clomipramine trial, although the direction of change was the same during both treatments for every patient studied.
CNS Spectr. 2003 Aug;8(8):612-3.Methylphenidate-induced obsessive-compulsive symptoms in an elderly man.
Serby M.
Department of Psychiatry, Beth Israel Medical Center, and Albert Einstein College of Medicine, New York, New York 10003, USA. mserby@bethisraelny.org
An 82-year-old man with treatment-resistant depression and early Alzheimer's disease was started on methylphenidate. Significant obsessive-compulsive behavior ensued but diminished over several weeks when methylphenidate was replaced by fluvoxamine. The patient had no prior psychiatric history, but he had a sister with obsessive-compulsive disorder. It appears that methylphenidate precipitated the patient's pathological behavior.
J Clin Psychopharmacol. 1987 Dec;7(6):420-2.Methylphenidate in primary obsessive-compulsive disorder.
Joffe RT, Swinson RP.
Department of Psychiatry, St. Michael's Hospital, Toronto, Ontario, Canada.
An acute methylphenidate challenge was performed on 13 patients with primary obsessive-compulsive disorder. There was no overall effect of methylphenidate on mood or obsessive-compulsive behavior. However, on various behavioral scales, four patients had an antiobsessive-compulsive response and one patient an antidepressant response to methylphenidate. The clinical and theoretical implications of these findings are discussed.
Ed.
poster:ed_uk
thread:436160
URL: http://www.dr-bob.org/babble/20041228/msgs/436160.html