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Re: GAD/Dysthymia/Smoking: Pamelor/Nortriptyline

Posted by cache-monkey on September 15, 2004, at 13:51:30

In reply to Re: GAD/Dysthymia/Smoking: Buspar (or Cymbalta or ...?, posted by King Vultan on September 15, 2004, at 10:20:08

> > hi,
> >
> > Something else you might try is nortriptyline. It is the only AD besides Wellbutrin that has been clinically shown to aid in quitting smoking. It has few discontinuation or sexual side effects, and is lesss likely to cause anxiety than Wellbutrin. Also, in my experience, it goes well with Buspar.
> >
> > -z
>
>
> I was also going to suggest nortriptyline for the same reasons, but I have no experience myself combining it with Buspar.
>
> Todd

I do remember reading somewhere that nortriptyline might have efficacy in helping depressed smokers quit. But, I've been under the impression that the side effects are generally less benign for the TCAs than for the SSRIs, especially the cholinageric ones (sweating, constipation, dry mouth) and that there's also a potetial for weight gain.

I'd be interested in hearing more about your experiences with side effects and such...


Also, doesn't this require multiple dosing (e.g. 3-4 times per day)? I also read something recently about needing a blood test to check the level of the drug in your system. Does this have to do with CYP-2D6 deficiency or is it something else? Let me know if you have any info, please.

Thanks,
cache-monkey


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URL: http://www.dr-bob.org/babble/20040915/msgs/391131.html