Posted by steve12 on September 9, 2004, at 15:18:30
In reply to Re: Cymbalta folks who have been on it 20 days » steve12, posted by Bob on September 8, 2004, at 21:38:25
Well yes and no. Cymbalta has a 1:1 ratio for 5HT and NE whereas venlafaxine doesn't. However, it seems that most re-uptake inhibtors of 5HT will produce sexual side-effects. The problem with the national registery is that it does nothing to solve the problem that the drug companies sponsor most of the studies and given huge incentives to docs and medical centers to find "good correlations" All research in psychiatry, in my opinion, is untrustworthy since all of the journals are heavily supported with drug money, as well as the docs and the medical centers. If Lilly sponsored all of the studies, paid honorarims for MD's to "educate" themselves about Cymbalta and gives out free samples -- then how do we know that anyone has an objective viewpoint in eval this drug (the FDA? Ha!) It's a disgrace.
> I have not tried Cymbalta, but your report of sexual side effects does not suprise me in the least. I would also not be suprised if people on Cymbalta gain weight in the long term. You've gotta remember that the drug companies do everything in their power to make their drug look good so that it will get approval. They keep studies short, and only publicize favorable results. That is why there is movements underway to develop a federally sponsored registry which would keep track of all studies. In that way, all info would be published, good or bad. Until then, it is the way it is.
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> There is no reason to expect profound new developments with this drug, as the basic chemistry is not novel. It uses, as one of it's mechanisms of action, SRI action. This has always, without exception, caused sexual side effects.
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> The fact that the Cymbalta compound is not identical to others in its class offers at least the hope that one would respond slightly differently to it. In the end, freedom will not be found until new avenues are explored.
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> I am sorry to hear about the side effects you are having. I am very, very familiar with the sweating and sexual side effects, as I've gotten them on most drugs I've taken. Hopefully they will diminish for you in time. It seems to me like the anticholinergic effects of Cymbalta may be somewhat high.
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poster:steve12
thread:388301
URL: http://www.dr-bob.org/babble/20040909/msgs/388787.html