Posted by King Vultan on September 1, 2004, at 23:19:50
In reply to NE alpha-2 antagonism + reuptake inhibitors = AD++, posted by SLS on September 1, 2004, at 20:16:29
> Here's a neat little piece I found:
>
> Alpha2-adrenergic receptor blockade markedly potentiates duloxetine- and fluoxetine-induced increases in noradrenaline, dopamine, and serotonin levels in the frontal cortex of freely moving rats.
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> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9375697
>
>
> This provides a nice pharmacological rationale for the use of Remeron or Buspar (with its 1-PP metabolite) as augmentors.
>
>
> - Scott
Or possibly yohimbine--alpha-2/alpha-1 selectivity ratio ~ 45:1 (at least according to some study I read once). As for Remeron, Stahl in "Essential Psychopharmacology" states "The therapeutic actions of mirtazapine are thought to be mainly mediated through its alpha 2 antagonist properties." However, mirtazapine has other things going for it; the selective alpha-2 antagonists such as yohimbine and idazoxan are rather one dimensional in comparison and have not really demonstrated any kind of robust AD effects. Remeron, OTOH, apparently does, to a large enough extent to at least be classified as an antidepressant, and demonstrating AD efficacy in many cases just being used by itself.Todd
poster:King Vultan
thread:385419
URL: http://www.dr-bob.org/babble/20040830/msgs/385489.html