Posted by Larry Hoover on August 29, 2004, at 8:07:55
In reply to Blood levels for desipramine?, posted by Ame Sans Vie on August 29, 2004, at 7:46:55
> Does anyone know if there is a therapeutic window for desipramine that can be determined by blood level?
The lower bound of therapeutic response to desipramine is 116 ng/ml. The upper bound is not clearly established (i.e. that point at which toxicity effects become significant, vis a vis response).
Do you think you can get tested for desipramine concentration? Way cool, if you can.
> I've been taking 200mg daily for close to three weeks now and possibly experiencing some benefit... at the very least it's given my Adderall more of a punch! No side effects at this dose either, save a very mild orthostatic hypotension that I can easily put up with.
You're a tad impatient. Three weeks is not long enough to judge response. Three months is.
> I'd just like to decide at what point I'm going to consider my desipramine trial a wash and jump on the Cymbalta bandwagon (and/or give selegiline a try at an MAO-B selective dose, along with pharmaceutical beta-phenylethylamine).
>
> ~MichaelDo you have any idea what your 2D6 status is? Extensive metabolizers only sustain desipramine concentrations below 50 ng/ml.
Lar
poster:Larry Hoover
thread:383581
URL: http://www.dr-bob.org/babble/20040825/msgs/383587.html