Posted by 1980Monroe on June 26, 2004, at 23:04:33
In reply to Re: what class does Provigil list under, posted by zeugma on June 26, 2004, at 22:43:26
"Its dopamine -releasing action in the nucleus accumbens is weak and dose-dependent; the likelihood of a euphoric response ('abuse potential'), dose-escalation and tolerance is thus apparently small. Modafinil has central alpha 1-adrenergic agonist effects i.e. it directly stimulates the receptors. Modafinil inhibits the reuptake of noradrenaline by the noradrenergic terminals on sleep-promoting neurons of ventrolateral preoptic nucleus (VLPO). More significant, perhaps, is its ability to increase excitatory glutamatergic transmission. This reduces local GABAergic transmission, thereby diminishing GABA(A) receptor signalling on the mesolimbic dopamine terminals."
Well i guess i decided to do some research on my own and stop being lazy and asking people, anyways this is what a coughed up, its from :
I know there's some other sites in the past that i have read briefly that it had weak dopamine activity on the terminals, but mainly its not really affecting dopamine directly such as amphetamine, and methylphendiate.
But its wierd on the site its considered a psychostimualant, even thought dopamine is not the main target. Oh well, more opionions are welcome.
poster:1980Monroe
thread:360790
URL: http://www.dr-bob.org/babble/20040621/msgs/360851.html