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Elder Statespersons of Psychobabble: re d-meth

Posted by Keith Talent on May 27, 2004, at 8:31:48

I am currently taking 40 mg per day total of dextroamphetamine. One of you gurus told me a while back that dextromethylamphetamine (Desoxyn) is about three times more potent at causing dopamine release, but also powerfully causes serotonin release (sounds kind of like MDMA). I was just wondering whether long term use can cause the kinds of heart valve problems that were seen with dexfenfluramine.

Also, could the combination of dextromethylamphetamine and an SSRI cause serotonin syndrome, or is that condition almost always the result of combining a MAOI with another serotonergically-acting agent?

Finally, if I was to switch from dextroamphetamine to dextromethylamphetamine, would I need to increase the dosing frequency (currently thrice daily suits me fine)?

I take:

clonazepam 2 mg twice daily

dextroamphetamine 20 mg upon waking, 10 mg six hours later and 10 mg six hours later still

irbesartan 300 mg in the morning (an angiotensin-II receptor antagonist to control hypertension)

sertraline 100 mg in the morning

My diagnoses are:

Major Depressive Disorder
Obsessive Compulsive Disorder
Social Phobia


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poster:Keith Talent thread:351053
URL: http://www.dr-bob.org/babble/20040527/msgs/351053.html