Posted by chemist on May 19, 2004, at 14:32:17
In reply to Chemist...do you know why pdocs, posted by sooshi on May 19, 2004, at 10:55:27
> don't prescribe Zonegran more often? I know it's not as well known as the other anti-seizure/mood stabilizers, but it seems to be so effective (especially for me!), without all the horrendous side effects, especially compared to Topamax. Is it because of the sulfate allergy problem? Is it as effective for migraines, seizures and bipolar d/o as Topamax is? Why would a pdoc would choose Topa as a first-line defense against these disorders, with it's miriad of se's, when there are such drugs as Zonegran? Maybe it's too new. I have a feeling it has to do with $$?
>
> Just curious.hello there....topamax is a sulfamate, and the allergies to sulfites - found in foodstuffs such as wine to prevent oxidation of the vino - is not likely the cause, as the sulfamate anion interacts with the enzyme in question (carbonic anhydrase) and the presence of sulfate nor sulfite anions results. as to why doctors prefer it to zonegran, i can make 2 guesses: (1) it is a newer therapy (as you note) and it is not on the radar of many psychiatrists; and (2) there is a risk of SJS with zonegran that is not indicated with topamax, from what i have read.....all the best, chemist
poster:chemist
thread:348554
URL: http://www.dr-bob.org/babble/20040515/msgs/348622.html