Posted by DepNYer on March 17, 2004, at 16:27:13
In reply to Re: Klonopin half-life, posted by KXo on March 17, 2004, at 15:12:02
It can vary from individual rates of metabolism as well as methods used to calculate half lives (according to the package insert from Roche, it's 30 to 60 hours, although studies independent of Roche have shown greater variability, possibly because of methodology variation, or, as it is metabolized by the CYP3A pathway, P450 inducers can effect the plasma levels and excretion rates). The exact half life is less important than the recognition of it's fairly long half life. This allows for once or twice a day use.
poster:DepNYer
thread:324449
URL: http://www.dr-bob.org/babble/20040313/msgs/325359.html