Posted by Sad Panda on February 5, 2004, at 23:14:13
In reply to Re: anyone needing up dose due to w/d like symptoms? » PoohBear, posted by on-the-wave on February 5, 2004, at 13:22:27
> This is the first time i have heard of overdosing and at levels most docs assume acceptable.
>
> This is new to me. Is there more info on this somewhere.5 to 10 percent of caucasians have a gene which makes them poor metabolizers of drugs metabolized by the liver enzyme CYP2D6. Roughly 25% of all drugs are metabolized by this enzyme. Not having enough of this enzyme makes you blood level of the drug much higher than it would be for average people.
Cheers,
Panda.
poster:Sad Panda
thread:13781
URL: http://www.dr-bob.org/babble/20040204/msgs/310032.html