Posted by Sad Panda on January 28, 2004, at 23:14:54
In reply to Re: I think we need to start a Dopamine Club here. » Karen Moore, posted by scott-d-o on January 28, 2004, at 3:42:22
> how about switching the effexor to the old tricyclic doxepin.. it blocks reuptake of serotonin and norepinephrine, like effexor does, however it is also a very potent antihistamine (sedative), and also has alpha-1 antagonism (which I assumed was the reason seroquel helps your insomnia.) In fact, the only reason effexor was supposed to be an improvement over older tricyclics, such as doxepin, is because effexor doesn't have the sedative and anticholinergic action of TCA's. doxepin also happens to be a 5-HT2a antagonist, again like seroquel, and this should help with the insomnia as well.. sounds like the best of both meds for you..
>Doxepin is an extremely weak serotonin reuptake inhibitor but it is powerful at blocking histamine, the only thing stronger is Mirtazapine. Efexor is a weak norepinephrine reuptake inhibitor. Benzos don't make me drowsy but Mirtazapine certainly does.
Cheers,
Panda.
poster:Sad Panda
thread:306217
URL: http://www.dr-bob.org/babble/20040127/msgs/306732.html