Re:

Posted by Caleb462 on June 10, 2003, at 1:16:01

In reply to Re: » Caleb462, posted by Questionmark on June 10, 2003, at 1:03:16

> > I've read recently that smoking can interfere with the effectiveness of Anafranil.
> >
> > On further reading.. I found out that smoking induces demethylation, meaning that when taking clomipramine (anafranil), the levels of the clomipramine's metabolite will be higher than usual. Clomipramine's metabolite is a potent norepinephrine reuptake inhibitor, where as clomipramine itself is a serotonin reuptake inhibitor. So basically, I took this to mean that a smoker will get less of the serotonergic effects of Anafranil and more of the noradrenergic effects - which may not neccesarilly matter in treating depression, but may very well matter in treating OCD - which is what I'm taking it for.
> >
> > Anyway... anyone have any experiences and/or thoughts on this?
>
> That all sounds accurate to me. That sucks if you're a smoker. My empathies.
> -?.

Crap.

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Anafranil and smoking... Caleb462 6/9/03
Re: » Caleb462 Questionmark 6/10/03
Re: Caleb462 6/10/03

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