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Re: Niacinamide's affinity for BZD receptor?

Posted by Larry Hoover on May 10, 2003, at 12:57:18

In reply to Niacinamide's affinity for BZD receptor?, posted by Ame Sans Vie on May 10, 2003, at 11:23:24

> Anyone have any thoughts on this?

Much of the research into the psychological effects of niacinamide (also known as nicotinamide) was done in the former Soviet Union. Whether or not the niacinamide binds in the same place as do benzodiazepines is the matter of some dispute, but the effect is not in dispute. There is a very clear anxiolytic activity, sometimes likened to that of diazepam.

Looking at this substance just now, I found that niacinamide increases neuronal turnover of choline, and thus potentiates acetylcholine activity. Moreover, in animal models of Parkinsonism and major depression, niacinamide increases serotonin turnover.

I was unaware of these effects. Thanks for bringing it up.

Lar

 

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poster:Larry Hoover thread:225568
URL: http://www.dr-bob.org/babble/20030505/msgs/225583.html