Posted by Larry Hoover on April 20, 2003, at 9:56:32
In reply to Re: Recent article - Thankyou Jaynee » Jaynee, posted by bluedog on April 20, 2003, at 3:19:26
> > http://www.cpa-apc.org/Publications/CJP/current/haag.pdf
>
> Thankyou JayneeYes, thanks Jaynee.
> I've saved this article to my hard-drive for future reference.
>
> This article confirms my belief and it's apparent that omega-6 acids do NOT actually reduce the effectiveness of fish oil and that that omega-3 and omega-6 do act synergistically in the human body and in the brain.I don't see that the article says that at all. In fact, I think it's silent on the issue. The Adelaide study, and others in lab animals, show unequivocal inhibition of EPA uptake in the presence of linoleic acid. What effect that may have is unclear, but linoleic acid cannot go on to form signalling compounds (the leukotrienes, prostaglandins, et al) as it does not have double bonds separated by six positions, as do the PUFAs arichidonic, dihomogammalinolenic, EPA, DHA.
> However the most important thing is that the RATIOS of omega-6 to omega-3 need to be addressed and too much of either of these EFA's may reduce the effectiveness of the other (ie an imbalance of what the body naturally requires). It's just that in the Western diet the ratio is out of whack and most of us get too much omega-6 and not enough omega-3. I think that the conclusions of the Adelaide study cited above in this thread need to be interpreted in this context and therefore the results should be interpreted with care.The omega6:omega3 ratio is a non-specific comparison between classes or families of fatty acids. The Adelaide study addresses competition between single members of the classes. Linoleate intake is just one factor influencing the fatty acid metabolic parameters. The Adelaide study mentions margarine, but the abstract doesn't provide insight into the form the margarine takes (there are different types). If the margarine is the more typical hydrogenated vegatable oil form, then ingestion of trans-fatty acids becomes an uncontrolled variable. (The only way I'd know what was really going on is to read the whole paper.) That's why I think the rat study I posted shows a more clear picture of the effect; increases in linoleate are associated with decreases in EPA uptake. I don't see what that has to do with GLA.
> I know this issue has come up before on the med board!!
>
> warm regards
> bluedogI'll tack on your reference from the other thread. You said:
"Jaynee has given a link to a useful article on EFA's that I believe also addresses my questions.
Would you agree???"
Frankly, no I don't think so. It answers different question, IMHO. If there's a discrepancy in my thinking, try asking your questions again. The passage of time may have obscured what you're looking to have answered.
Lar
poster:Larry Hoover
thread:216908
URL: http://www.dr-bob.org/babble/20030417/msgs/220818.html