Posted by jumpy on February 6, 2003, at 23:18:34
In reply to Re: Mirapex/Selegiline/Parnate » jumpy, posted by not exactly on February 6, 2003, at 3:50:14
> I couldn't get it right after the trial (about 7 years ago) because it hadn't been approved yet. I *was* able to get it a couple of years later. I explained all this in a previous post [http://www.dr-bob.org/babble/20030204/msgs/139600.html].
Sorry, I didn't have time to read every post
> I did. For about a year. But it never worked as well. When selegiline is taken orally, the metabolic pathways are somewhat different, and hence the plasma levels of active metabolites end up at different ratios. So the overall effect is not exactly the same. Also, you need to take such a large dose orally that the MAOI diet is mandatory (which I found to be a big disadvantage). Cheese-safe levels of oral selegiline aren't effective as an AD.
True, people end up takeing anywhere from 20 to 50 mg of selegiline in the oral preparation and one does have to adhere to the diet. I haven't heard of people having difficulties with the switch from the patch to the pill and problems with the metabolite "ratios". Sorry to hear you were one of the few with this reaction.
> Parnate is near the top of my "to be tried" list, but I'm not looking forward to the MAOI diet restrictions. How can I live without pepperoni pizza? :-(
Actually, the diet is pretty healthy and easy to follow. No sausage, cheese, certain wines and beers ... they all add to a slimmer waistline and healthier heart. I would for go 1,000,000 pepperoni pizzas *and* the pitcher of beer that follows to find some relief from my depression. But if pizza mean that much to you, I guess your stuck. :-(
Good Luck
Keep us posted
Jumpy
poster:jumpy
thread:138954
URL: http://www.dr-bob.org/babble/20030204/msgs/139895.html