Posted by Anyuser on October 10, 2002, at 16:21:49
In reply to Lundbeck accused of cheating in Effexor trial » pharmrep, posted by dr dave on October 10, 2002, at 15:02:35
Do you have access to the following study in full?
European Neuropsychopharmacology
Volume 12, Issue 5, pp. 433-444, October, 2002
Enantiomers' potential in psychopharmacology-a critical analysis with special emphasis on the antidepressant escitalopram
Authors
P. Baumann, D.F. Zullino, C.B. EapAbstract
Stereochemistry is now influencing most areas of pharmacotherapy, with a growing awareness in the field of psychiatry and, more specifically, depression. This is due to the fact that the enantiomers of many chiral drugs may have distinct pharmacological, pharmacokinetic and/or pharmacogenetic profiles. Consequently, in some instances there may be an advantage in using a single enantiomer over the racemic form-thus providing a basis for the development of new therapeutic agents, as well as the potential to improve current treatments. This review highlights some of the potential advantages and disadvantages that using single enantiomers might offer. The principles are exemplified through reference to the stereoselective properties of several established chiral psychotropic drugs, including thioridazine, methadone, trimipramine, mianserin, mirtazapine, fluoxetine and citalopram. Emphasis is given to the treatment of depression and how the potential of one pure enantiomer-escitalopram, the S-enantiomer of the selective serotonin reuptake inhibitor citalopram-appears to be fulfilling its preclinical promise in the clinic.
Keywords: Enantiomer, Depression, Antidepressant, SSRI, Citalopram, EscitalopramPII: s0924977x02000512
© Copyright 1999-2002, Elsevier Science, All rights reserved.
poster:Anyuser
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