Posted by JLM on October 3, 2002, at 18:10:48
In reply to Re: Logic and evidence » pharmrep, posted by dr dave on October 3, 2002, at 2:53:09
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> I wonder if you could let us know what the evidence is that r-cit 'can attach to receptor sites not allowing the s-cit to attach, therefore inhibiting metabolization'. The only relevant site with respect to SSRI activity is the serotonin re-uptake transporter, and r-cit has only 1/30th the affinity for it that s-cit has, not enough to significantly compete. I am also not sure why s-cit would have to be bound to a receptor to be metabolised, or what receptor that would be. It sounds like you've seen some important new data, and would be very grateful for details.
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> > ** hi there...there are studies that show r-cit doesnt work...(sanchez study). the r-cit can attach to receptor sites not allowing the s-cit to attach, therefore inhibiting metabolization.
> > ps...i dont know where this 4-to-1 ratio thing is coming from...its not forest. Lexapro is twice at potent as celexa (or any other AD). so yes..10mg lexapro is at least as efficacious as 40mg of celexa. does this mean 15mg=60 or 20mg=80? not necessarily...the math seems that way, but patients so far dont always need more...i know of many 80mg celexa pts doing fine on 10mg lexapro, (or higher doses fo prozac, paxil, zoloft, effexor as well)
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I'd like to see this evidence as well.The silence seems deafening thou, doesn't it? ;)
poster:JLM
thread:109458
URL: http://www.dr-bob.org/babble/20020930/msgs/122188.html