Posted by pharmrep on October 3, 2002, at 12:25:17
In reply to Re:lexapro dosage » yeltom, posted by pharmrep on October 3, 2002, at 11:52:02
> Alright then...if you are looking for a basic ratio, not the scientific or therapeutic rationale, but just simple math...I see where 4-to-1 comes from (ie 10mg Lexapro = 40mg Celexa). But lets be clear, that is not the potentcy or efficacy ratio. See the Sanchez study to learn more about r-cit, s-cit (lexapro), and r-cit + s-cit (celexa) to see how they really work. It isnt such a strange point, because the "ratio" isnt exact...only 10mg lex = 40mg celexa has been studied, in reality, there are many people who were on higher than 40mg of celexa (and equivilant doses of other AD's) that have tried 10mg of Lex and dont need to go to 15mg or more. Dont assume you need more. Doctors have been told that the starting dose is 10mg...if needed, after at least 1 wk...go higher...I would guess that only 20% or less of people will need higher that 10mg (since about 80% of people taking celexa used 40mg or less) Of course time will tell, but jumping to higher doses because of math isnt right...try 10mg...give it a fair trial for a few weeks before determining if you need more...it is twice as potent as celexa or any other AD so this is different than what's been available before. Good luck to all, and keep us posted.
**Cant find online...but will try... it is called .."Escitalopram: A comparative study of in vitro and in vivo 5-ht uptake inhibitory activity"...study was presented at the XXIII CINP Congress, June 23-27, 2002 in Montreal, Canada
It was done by A. Mork, M. Kreilgaard, C. Sanchez, L.T. Brennum and O. Wiborg (Dept Neurochemistry and Discovery ADME, Dept. Neuropharmacology and Dept. Molecular Pharmacology, Psychiatric Hospital of Aarhus University, Denmark.
poster:pharmrep
thread:109458
URL: http://www.dr-bob.org/babble/20020930/msgs/122130.html