Posted by dr. dave on September 10, 2002, at 4:42:08
In reply to Re: Fewer s/e with Lexapro - where's the evidence?, posted by moxy1000 on September 9, 2002, at 22:49:59
> Dr. Dave, I believe evidence has already been offered to you but it seems as if the conclusions arrived at in any clinical studies are usually contrary the conclusions you draw for yourself, as far as I can tell from your posts.
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> I would not think that a direct comparison of Celexa's side effect profile versus Lexapro's side effect profile would be of any value to you, would it? I mean, there are different patient populations involved, different dosages of each agent given. Lexapro's side effect profile was based on a 8 week study, dosed at 10-20 mg (the starting/maintanance dose and the maximum dose.) Celexa's side effect profile was based on a 6 week study, dosed from 10-80 mg (half the starting dose of 20mg to 20mg past the max dose of 60mg.)
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> If there are is still value to you, even recognizing those vast differences in study design, I would be happy to post the numbers for you. But keep in mind, both studies were sponsored by the manufacturer, and from your prior posts, I know you don't care for those types of studies, either.
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> I guess what I'm saying is if you will overlook those "flaws" I will go through the work to get the information for you. If those things are too bothersome to get past in the first place, then what's the point? I don't mean to sound cynical, but you've been a tough critic on this board and I guess I just thought you were past convincing at this point. (And that's not necessarily a bad thing.)
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>I don't think evidence of a significantly different side-effect profile has been presented. Studies have been done which would answer the question in as unbiased and objective way as possible (randomised double-blind trials, comparing equivalent doses), and these should provide the most reliable data. If these presented evidence that there was a significant difference - well, that would be evidence. But they don't.
I've presented almost all of the available data from these trials, as it is an important question which has a fair amount of research done on it. The data are clear in failing to show any significant difference. Maybe there is a difference - my point is that even if we take the results at face value, they don't support the claim.
poster:dr. dave
thread:109458
URL: http://www.dr-bob.org/babble/20020906/msgs/119443.html