Posted by Ritch on July 31, 2002, at 23:10:57
In reply to continued info, posted by pharmrep on July 31, 2002, at 21:49:05
> oops..forgot to retitle the last one..sorry. Kate, I like your trust note, I will continue to earn yours.
> You said you like Meta-regression analysis, well try this. Nick Freemantle British Journal of Psych. 2000, 177, 292-302
> (It is sponsored by Wyeth Labs but backfired) ultimately it is a compilation of 105 studies/11000+ patients to see if hitting
> other receptor sites other than serotonin is better (ie Effexor hitting Norepinephrine at above 150mg)...it says "This analysis does not provide evidence that anti-
> depressants acting at more than one pharmacological site differ in efficacy from drugs selective for serotonin reuptake in the
> treatment for major depression". Even though Wyeth sponsored, he goes on to say that "dual action" has "become a marketing concept
> for a number of antidepressants, and this study raises the question as to whether it has a legitimate scientific basis, in considering
> mechanisms behind antidepressant efficacy." Again...wow. Anyway, I wanted to show this study to you so you can see that Dr's dont care
> who is paying them...they just run the tests, they wont destroy their credibility for a paycheck.
PharmRep,Thanks for the added information! Well, well, it looks like we are headed for a slugfest between Lexapro and Cymbalta, eh? :) Cymbalta (duloxetine-Lilly) is supposed to be out on the market just after the first of the year from what I understand. Serotonin reuptake inhibition (selective or not), does tend to cause similar side effects and that is really no big revelation. Just a hunch, but the *differing* side effect profiles among SSRI's must be accounted for by something other than just their relative lack of "selectivity", no?
Mitch
poster:Ritch
thread:109458
URL: http://www.dr-bob.org/babble/20020731/msgs/114721.html