Posted by cybercafe on July 22, 2002, at 21:16:21
In reply to Re: enhancing and decreasing » Shawn. T., posted by katekite on July 22, 2002, at 17:12:50
> I'm curious what you think about why people with Parkinson's often develop schizophrenia type illness when treated with L-dopa or other dopaminergic drugs? That's the one thing I just can't make that fit with the 5HT2 theory. Because their brains clearly have death of dopamine neurons. So it just seems like it would be a dopamine problem. Do you have any thoughts?
Yes it is very likely related to dopamine on some degree, I think schizophrenics might have more dopamine causing excessive firing of D2 receptors in the neocortex i don't remember exactly though
what i can tell you for certain that is i just got a report in the mail showing that the genes encoding norepinephrine (alpha1, 2, 3 beta1, 2), dopamine D2 and D4 corticosteroid and a particular G protein subunit are not shown to be altered in schizophrenia ...
in fact i believe schizophrenics seem to have enlarged ventricles (lateral cerebral ventricles) caused by death or a lack of growth of normal brain cells around the ventricles... i believe it is actually the hippocampus that is decreased in size in schizophrenics... i think failure of the hippocampus to filter out information from the cognitive brain centers (neocortex) to the emotional centers (limbic system) can cause overstimulation ....
poster:cybercafe
thread:112626
URL: http://www.dr-bob.org/babble/20020718/msgs/113352.html