Posted by tina on June 20, 2002, at 17:38:53
In reply to Anybody know anything about...., posted by TenelKa on June 20, 2002, at 12:50:06
DRUG PRECAUTIONS AND INTERACTIONS
Known Interactions
The effects of hawthorn and digitalis are synergistic, such that only half the normal dose of digitalis is required if hawthorn is also being used.
Possible Interactions
Diuretic-induced hypokalemia may increase the activity of hawthorn; guinidine, procainamide, and propranolol may also enhance its effects. Conversely, the effects of the herb may be reduced by propantheline, spironolactone, and triamterene, as well as by antacids, anti-diarrheal absorbent suspensions, neomycin, cholestyramine, and other anionic exchange resins. Hawthorn is synergistic with parenteral calcium salts, pancuronium, succinylcholine, rauwolfia alkaloids, ephedrine, epinephrine, and other adrenergic agents. The inotropic action of this herb may be reduced by propranolol; however, the effect of the two substances on AV are additive. Cyclopropane or halogenated hydrocarbon anesthetics may sensitize the myocardium to the cardiotonic effects of hawthorn, although the chances of this happening are very low.
Comments
The cardiac alkaloids in hawthorn may antagonize the action of heparin. Certain drugs induce activity by hepatic microsomal enzymes that metabolize cardiac glycosides. These agents probably affect the action of hawthorn, but in an as yet unknown manner. To the extent that hawthorn's action depends on the presence of cholinergic substances, it will be affected by the decrease in cholinergic-receptor stimulation produced by anticholinergics. Drugs utilized to treat angina pectoris, such as nadolol and propanolol HDI, may reduce AV conduction induced by this herb.
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poster:tina
thread:110332
URL: http://www.dr-bob.org/babble/20020617/msgs/110351.html