Posted by JonW on June 12, 2002, at 14:18:59
In reply to Re: Parnate and sexual dysfynction...? » JonW, posted by cirrus6000 on June 12, 2002, at 11:10:44
Hi cirrus6000,
I'm aware of the idea that Parnate is more effective for social phobia, but I don't think there is any data that confirms this opinion. I believe there are one or two open studies that show Parnate effective and it certainly follows that if Nardil works other MAOIs should as well, but how does that compare to the multiple controlled studies of Nardil? I also understand Dr. Liebowitz (who is no dummy when it comes to SP) to share this opinion. The clinical impression of several of my psydocs and the impression you get here at psycho-babble certainly supports the implication that Nardil is the "gold standard" -- be it with many side-effects and restrictions, of course. Maybe the anxiety institute prefers Parnate because it gives you more energy and inspiration to try some of the behavioral therapy, who knows? Parnate is effective, but I don't think there is any reason to dethrone Nardil as the "gold standard". I've pasted a recent abstract from the begining of this year below about the current treatment of SP:
(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11801236&dopt=Abstract)
--------------------------------------------------
Pharmacotherapy of social anxiety disorder.Blanco C, Antia SX, Liebowitz MR.
Department of Psychiatry, Columbia College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA.
Over the last few years, a number of medications have demonstrated their efficacy in the acute treatment of social anxiety disorder. At present, selective serotonin reuptake inhibitors probably constitute the first line treatment, based on their safety, tolerability, and efficacy in the treatment of social anxiety disorder and common comorbid conditions. Data from single trials suggest that clonazepam, bromazepam, and gabapentin may have efficacy similar to the serotonin reuptake inhibitors, but further studies are needed to confirm these findings. The monoamine oxidase inhibitor phenelzine appears to be at least as efficacious as these other agents, but should be reserved for cases that fail to respond to these safer medications. Among the reversible inhibitors of monoamine oxidase A, brofaromine may also be an effective drug, while moclobemide appears to be less potent.Future research directions should include delineating ways to achieve remission (as opposed to response); developing strategies for augmenting partial responders and treating nonresponders to first line approaches; studying the long-term response to medication and prevention of relapse when medication is discontinued; clarifying ways to integrate psychosocial and pharmacological treatment approaches; developing predictors of which patients do best with which treatments; and the treatment of social anxiety disorder in children and adolescents.
Publication Types:
Review
Review, TutorialPMID: 11801236 [PubMed - indexed for MEDLINE]
--------------------------------------------------Jon
poster:JonW
thread:104368
URL: http://www.dr-bob.org/babble/20020609/msgs/109596.html