Posted by kregpark@yahoo.com on April 24, 2002, at 13:23:31
In reply to Re: Amisulpride/Sulpiride - nearest US equivalent?, posted by JohnQ on April 23, 2002, at 15:31:18
Hi John,
My post previous to this may cover a lot of this but what it doesn't I will try to answer here...
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> I'm not trying to challenge you Ray, but I'm wordering why you now think people with compromised dopamine systems are at a greater risk for dystonic reactions? Are you basing this solely on your own reaction, or have you found new research to support your claim?
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To be more clear, by "comprised" I actually meant dopamine depleted (generally speaking since that's all we really can do including the Dr's for the most part). Abnormally low dopamine levels are characteristic of affective disorders, some more than others. Social Phobics for example, are 5 times more likely to develop Parkinson's in later life and have been shown to have abnormally low d2 receptor density in striatum. They also respond best to the MAOI antidressants (compared to other antidepressants) - which unique boost dopamine generally globally in brain - and particularly so in striatum since MAOI-B is striatum selective.It is also well known than some patients such as bipolar low for example are highly sensitive to developing dystonia / dyskinesia from antipsychotics at any dose - thought to be because of their lowered dopamine levels in the "low" depressed state. They exhibit characteristics overlapping atypical depression and social phobia.
Interestingly when bipolar patients develop tardive dystonia - their symtpoms usually either go away entirely or are significantly reduced when they switch to the "manic" or "hypomanic" state (when their dopamine levels switch from too low to too high).The info is out there on all this stuff. It is better to stick with PubMed and so forth as your primary information - case studies are hard to use in terms of evaluating safety. You will save a lot of time also...time off the computer.
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Reason I ask is I've been very interested in Amisulpride, as it seems like it would be a great med for me, and I was thinking of ordering it soon. I'd hate to turn away a med that may benefit me, but I think I'd hate dystonia a lot more. Can you give me all the info you have on this subject, if you have the time?
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Is your call. I would discourage it. This is a good place to post any findings.
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Ray
ray_3888@yahoo.com
http://www.socialfear.com/
poster:kregpark@yahoo.com
thread:103216
URL: http://www.dr-bob.org/babble/20020416/msgs/103997.html