Posted by JohnX2 on March 21, 2002, at 18:59:32
In reply to Re: REMERON vs. SERZONE questions: » JohnX2, posted by Janelle on March 21, 2002, at 18:25:48
My codename was JohnX, but then Dr. Bob changed some registration policy and I had to reregister for some reason. The JohnX was already taken so I picked JohnX2.Remeron has a unique action at the norepinephrine receptors. It blocks a feedback receptor called the "alpha-2" norepinephrine receptor. This sits on the sending neuron and detects norepinephrine in the synapse. When it detects the norepinephrine it tells the sending neuron to slow down the release of norepinephrine (this keeps things in balance, otherwise we may shoot out of control). By blocking this receptor with medicine (Remeron), this causes the sending neuron to release more norepinephrine.
The way the pharmaceutical binds to the receptors and is metabolized by the body, etc, it just works out that the "alpha-2 blockade" is thought to kick in mostly at the higher dosing ranges (like 30-45 mg). At the lower doses, there is less norepinephrine kick. Remember that norepinephrine is generally stimulating.
Regards
John
> JohnX2 to the rescue as usual! (what's the X2 for by the way!) You always have the answers to my questions here! Thanks a bunch! I thought it was the Remeron that is LESS sedating at HIGHER doses, but needed to be 100% sure. Also, you provided an answer to an unasked (but important) question and that is WHY Remeron has this pattern - aboout the NE stimulation at the higher doses.
poster:JohnX2
thread:99295
URL: http://www.dr-bob.org/babble/20020318/msgs/99314.html