Posted by Rick on December 27, 2001, at 15:48:50
In reply to Re: RE: Using Serzone to Raise Levels of Other Meds » Rick, posted by Cam W. on December 26, 2001, at 19:04:43
Cam -
Thanks, that definitely helps clarify things.
But let me distill this to my primary question, to see if you have a feel for it or at least can make an educated guess (I'm certainly not looking for a "blanket statement"):
Assuming the patient has a "typical" cytochrome system with respect to the relevant enzymes, is it reasonable to think that a very small dose of Serzone, e.g. 75 mg, might lead to a significant metabolic inhibition? Or does this seem unlikely? All of the Serzone interaction studies I've seen are based on a typical monotherapy dosage of 400 mg, which says nothing about what the interaction effects (if any) from a lower dosage would be.
Thanks,
Rick
> Rick - I think that the pdocs I know use it to primarily raise levels of other drugs (without having to take higher doses of those drugs), while at the same time hoping for a little extra antidepressant activity.
>
> As for how to do it; I believe that is very individualized. Many factors have to be taken into consideration (past med use and response, what is hoped to be accomplished with the augmentation, disorder - and/or subtype - being treated, supposed status of one's cytochrome system, etc., etc., etc.).
>
> I do not think that I could make a blanket statement for using this type of therapy, nor do I think that it is an option for everyone. I do find that this sort of augmentation is fairly much a "last gasp" strategy, when most others have failed.
>
> I tend to think that this sort of therapy is from the "let-us-throw-a-bunch-of-treatments-against-the-wall-and-see-which-one-sticks" school of treatment. I am not a big fan of this, but sometimes one has to resort to whatever works.
>
> - Cam
poster:Rick
thread:87093
URL: http://www.dr-bob.org/babble/20011222/msgs/87973.html