Posted by Adam on November 8, 2001, at 17:49:46
In reply to Diphenhydramine abuse, posted by Delphi on November 7, 2001, at 20:05:05
I do know that OD-ing on diphenhydramine can be relatively serious (supposedly it can cause siezures), but I've never heard of any permanent neurological damage or other sequellae as a result.
I just have to know: Why on earth would you want to OD on Benadryl? All anyone seems to get from high doses is worse side-effects, and I've never heard of any kind of narcotic effect or whatever. What were you hoping to discover in this experiment?
> I have recently deliberately abused diphenhydramine in order to produce central anticholinergic syndrome. I took doses of 300mg, 375mg, and 425mg respectively on three different nights, with 24 hours between the first two, and 48 hours between the latter two. The second night was combined with 90mg pseudoephedrine, and all three involved approximately 100mg of caffeine (one cup of coffee). I realize it's a stupid thing to do, and I don't intend to ever do it again, but I want to know whether this may have caused any permanent damage and, if so, whether there are any steps I can take to reduce the damage.
>
> In addition, does anyone know whether anticholinergic symptoms may be followed up by symptoms of excess muscarinic acetylcholine stimulation? I've noticed hangover symptoms, including increased salivation, and I wanted to make sure it wouldn't progress to anything more dangerous, akin to the neurotoxic action of organophosphorus compounds. Also, I haven't been able to figure out why I repeated the experience twice, particularly in such close proximity to the original event, as it wasn't particularly pleasant. Could the lack of better judgement have been somehow associated with the chemical action or is there a deeper psychological problem I should worry about?
>
> -beginning to realize that curiosity may well have killed the cat
poster:Adam
thread:83473
URL: http://www.dr-bob.org/babble/20011104/msgs/83581.html