Posted by Elizabeth on September 12, 2001, at 4:56:03
In reply to CAM: question about codeine and antidepressants, posted by shelliR on September 11, 2001, at 18:03:52
> My depression has not abated at all in the last year, and I am beginning to wonder if there is a possiblity that there *is* some interference.
That may be due to tolerance (this doesn't always happen, but apparently it is possible).
Cam is right that the effects of codeine can be blocked by some ADs, though. Its effect is mainly due to metabolism into morphine via cytochrome P450 2D6 (not 2D7 :-) ). Lack of response to codeine can be an indicator of possible CYP 2D6 deficiency.
Short-term use of opioids (at least, of full agonists or mu-selective agonists) is unlikely to cause problems.
General anaesthesia -- particularly the barbiturates which are used for induction -- can most certainly exacerbate depression.
Cam:
The problem with Demerol is that it's a monoamine reuptake inhibitor as well as an opioid agonist. Together with enzyme inhibition by some SSRIs, this can result in the serotonin syndrome.BTW, if you do find that paper, I'd be very interested in what it has to say. What subtypes of depression are implicated?
-elizabeth
poster:Elizabeth
thread:78595
URL: http://www.dr-bob.org/babble/20010907/msgs/78633.html