Posted by medlib on August 9, 2001, at 21:55:29
In reply to Babble Brainiacs, please read (Elzbth, I humbly..., posted by Adam on August 8, 2001, at 21:24:22
Hi Adam--
I saw my pdoc this afternoon for my monthly 15 minutes. During a discussion of rx augmentation in order to diminish intolerable side effects of an otherwise helpful drug, I mentioned your notion of grapefruit juice to inhibit intestinal CYP3A4 metabolism of selegiline (sans names or any other details, of course). He pronounced the idea "intriguing" and "very creative" and asked that I let him know the results if it was implemented. Just thought I'd let you know you've interested one pdoc, at least.
One other point: In your research, did you notice that grapefruit juice inhibits CYP1A2 as well as 3A4? I realize that 1A2 is not mostly in the gut as 3A4 is, but 1A2 inhibition is potentially relevant because acetaminophen and caffeine are among this isoenzyme's substrates. So, lots of grapefruit juice may prolong or enhance the effects of these common substances.
And a question: How do your latest vital signs compare with earlier? Of course, l reading doesn't tell you jack, and it's probably too early to expect much change, but I'd think that peak and trough VSs over several days would show some downward trend, if you're on the right track.
Well wishes and fingers crossed---medlib
poster:medlib
thread:74266
URL: http://www.dr-bob.org/babble/20010809/msgs/74394.html