Posted by PaulB on July 2, 2001, at 14:24:24
In reply to Re: Benzodiazepine, Mood stabiliser, Stimulant, posted by SalArmy4me on July 1, 2001, at 23:05:51
> If you want a dopamine-enhancing, stimulating drug, why not go for buproprion (which works on norepinephrine too)? Second choice: Pramipexole.
PaulB writes >
Wellbutrin I have never come to fully understand the mechanism of. There are conflicting views on its mechanism of action. It certainly possesses re-uptake inhibitory effect of the catecholamines but I think its metabolite is an dopamine agonist as well. Pramipexole, I know has been used as an antidepressnat to good effect although at the highest dose with the most robust antidepressant effect there were some tolerability problems.
The alpha1 adrenergic agonist adrafinil appealed to me because it seemed an ideal candidate for augmentation with Clonazepam. Alpha1 has memory-enhancing, cognitive enhancement, alertness promoting in addition to its solid antidepressant effect. Thats sounds great. Although Pramipexole may well possess good antidepressant effect via D2 enhancement Im not aware that it shares these other attributes with Adrafinil.
poster:PaulB
thread:68657
URL: http://www.dr-bob.org/babble/20010701/msgs/68736.html