Posted by Elizabeth on June 27, 2001, at 7:31:55
In reply to Re: subthreshold epilepsy 'n' stuff, posted by may_b on June 26, 2001, at 11:35:14
> Hi Elizabeth
Hi there.
> I am just starting a trial with moclobemide (1 week). Feel horribly anergic, without focus etc.
Is that the depression, or does the moclobemide seem to be causing it (or making it worse)?
> Please explain what have you heard about Moclobemide's reputation? I have been culling through the postings and found very little.
Since it's not marketed in the USA, a lot of people don't have the opportunity to try it. What I've heard is that it is a first-line antidepressant (along with the SSRIs) in some countries, but that it doesn't share the (often seemingly miraculous) effectiveness of the irreversible MAOIs (Nardil, Parnate, Marplan, nialamide, etc.) for people who have already tried a lot of other things without success.
A lot of people seem to have problems with agitation on moclobemide, especially when they first start taking it. Antidepressants in general can cause this (tricyclics, Nardil, Serzone, trazodone, and Remeron are probably the least problematic). Since you've already started taking moclobemide (and particularly if you're in the US and went to all the trouble of procuring it!), you should try to sit it out, as this side effect usually subsides with time. Some people need benzodiazepines when they first start an antidepressant; used judiciously, these can make the experience much easier until you are able to tolerate the antidepressant without them.
Moclobemide seems to be a "hit-or-miss" type of treatment: a few people get very good results, but for others it doesn't work at all. (A lot of the more "selective" drugs are like that -- I'm thinking in particular of Serzone and BuSpar.)
> Nice to have you back. :)
Thanks! :)
-elizabeth
poster:Elizabeth
thread:64320
URL: http://www.dr-bob.org/babble/20010625/msgs/68055.html