Posted by SalArmy4me on May 14, 2001, at 14:04:47
In reply to Re: Parnate and Sugery...Please respond, posted by Lisamac on May 14, 2001, at 9:46:03
Here's what I found in my review of the literature:
Smith MS. Muir H. Hall R. Perioperative management of drug therapy, clinical considerations. [Review] [181 refs] Drugs. 51(2):238-59, 1996 Feb:
"...However, recent clinical experience has demonstrated the relative safety of continuing MAOIs prior to surgery by use of specific 'MAOI safe' anaesthetic techniques and/or substitution of short-acting MAOIs which do not irreversibly inhibit the enzyme."Abdi, Salahadin MD, PhD. Acute Exacerbation of Depression After Discontinuation of Monoamine Oxidase Inhibitor Prior to Cardiac Surgery. Anesthesia & Analgesia. 83(3):656-657, September 1996:
"This case report suggests that preoperative discontinuation of MAOIs can result in acute exacerbation of depression, which can involve intense suffering and can be life threatening through increased risk of impaired recovery as well as by posing the risk of suicide. Since the theoretical risks of discontinuing this class of drug prior to elective surgery are substantial and there are no convincing data to support or quantify the problems of such practice, we may need to rethink our approach in patients receiving preoperative MAOIs."el-Ganzouri AR. Ivankovich AD. Braverman B. McCarthy R. Monoamine oxidase inhibitors: should they be discontinued preoperatively? Anesthesia & Analgesia. 64(6):592-6, 1985 Jun:
"...We conclude that discontinuing chronic MAOI therapy prior to anesthesia and surgery is not necessary."
poster:SalArmy4me
thread:62722
URL: http://www.dr-bob.org/babble/20010507/msgs/62924.html