Posted by AndrewB on March 14, 2001, at 10:11:18
In reply to Re: Any potent Alpha-1 adrenergic agonists? , posted by JohnL on March 14, 2001, at 4:34:30
John,
Too much alpha 1 receptor agonisim can be problematic, having numerous possible side effects including sexual dysfunction, urinary hesitancy, anxiety, and (often) eventual poop-out.
That being said, I believe phenlyephrine is a fairly selective alpha 1 agonist. I know nothing more about it though.
Adrafinil (and possibly Provigil) may be a centrally acting alpha 1 agonists. Thereby giving the arousal effects of alpha 1 agonism without the periphereal side effects.
Stimulants stimulate the andrengic system in general.
Trycyclics which have a strong NE action component are often successfuly combined with serotenergic agents.
Reboxetine, as an NE reuptake inhibitor, has been used as an arousal agent though it can cause all (and then some) of the side effects listed above. People have found that serotenergic agents when combined with reboxetine can eliminate the anxiety or jumpy feeling that it may cause.
Those who quickly want to see if they will benefit from alpha 1 agonism can try Naphazoline eye drops. Bought over the drugstore counter, it acts within 10 or so minutes (it also has a short half-life). A person who responds to it, that is gets a positive arousL effect, may well benefit from the longer acting drugs described above.
Naphazoline is sold under a variety of tradenames like Vasocon and Naphcon. Look at the active ingrediants on the bottle. It should list .01% Naphazoline Hydrochloride as its active ingrediant. Do not buy eyedrops that contain other active ingrediants. For example, brands that have an 'A' at the end of their name (i.e. VasoconA), contain an antihistamine also as an active ingrediant.
Naphazoline is not recommended for long-term use. It tends to poop out after repeated dosing. Some people though have used it for over 3 years for arousal effects.
Excessive naphazoline can increase blood pressure, pulse rate, and sweating, and it can cause agitation, anxiety and insomnia.
Apply the eyedrops by first washing your hands (also keep the eyedrop bottle applicator clean and germ free). Then, tilt your head back and apply pressure with the middle finger to the inside corner of the eye (the tear duct). Apply one or two eyedrops per eye and continue the finger pressure for 1 or 2 minutes afterwards.
Insert the eyedrops by pulling down the lower eyelid with the middle finger to create a pouch. Drop in the eydrops, close your eyes and keep them shut and don't blink for one or two minutes. If after ten or so minutes you do not feel anything, repeat the dosing one more two times.
AndrewB
poster:AndrewB
thread:56463
URL: http://www.dr-bob.org/babble/20010310/msgs/56482.html