Posted by ben on February 21, 2001, at 10:56:19
In reply to Re: Celexa and Flupenthixol » ben, posted by JahL on February 21, 2001, at 10:17:22
> > Hi
> > Does anyone have experiences with Flupenthixol or (and) Melitracene ? I am taking Deanxit in addition to Celexa as an augmentation strategy (unipolar depression). Flupenthixol should have an antidepressant and mood-stabilizing effect with an early onset of action.
>
> Hi Ben.
>
> Theoretically you are right about Flupenthixol. In a no. of double-blind studies it was found to be of 'equivalent' efficacy to ami/nortriptylene, @ low doses.
>
> However few studies have been done for severe depression (true test of AD) & most of the benefits are seen in mixed anxiety-depressive states.
>
> The theory behind this is that the traditional neuroleptics reduce depression scores chiefly through reducing anxiety (a big component of the HRSD). A less anxious person will likely feel better. This has been my experience with Sulpiride.
>
> My pdoc refused to prescribe Flupenthixol a while back due to unacceptable potential risk for developing Tardive Dyskinesia.
>
> The newer APs supposedly carry much less risk for this, & through actions on receptors other than Dopamine, are better all-round AD augmentors. Recent studies have noted synergy btwn SSRIs (ie Celexa) & the likes of Risperdal & Zyprexa.
>
> Jah.Many thanks Jahl
How could the effect of Risperidone in addition to SSRIS (like Citalopram) be
explained ? Is it the serotonin or the dopamine mechanism or both ? What do you think about
amisulpride instead of risperidone, i read a lot
of good things about amisulpride. I think Zyprexa wont be good for me because of the sedation and weight gain. I need a mood booster for my melancholic depression.
, not a sedating or activating drug. What could be a good option to celexa if de Deanxit fails ?
I tried Lithium (stopped about terrible nausea),
Remeron (too sedating and headaches), Effexor and Surmontil (Trimipramine).
without good success.ben
poster:ben
thread:54555
URL: http://www.dr-bob.org/babble/20010221/msgs/54578.html