Posted by Janus on January 26, 2001, at 4:40:00
In reply to I AM NOT GIVING INTO TAKING ANOTHER PILL! , posted by Kara on January 25, 2001, at 17:14:54
I have been on effexor retard for one year and i have tried literally avery available antidepressant exept tricyclycs. Yes even nonreversible monoamioxidaseinhibitors.
Effexor has been the only one that has really keeped on working. Every other either stopped working after 3-6 months (SSRIs)or did not work at all (MAOinh.)
I have also found that combining efexor with tymelyt (maprotilin) enhances the AD effect. Also combining with Mianserin boosts the effect, but mianserin makes me tired gives me huch wiaght-gain. But mianserin actually boosted more than maprotilin.
So i and my shrink have concluded my depression can best be treated with ADs that address noradrenaline.
Maybe there are two distinctive neurotransmitterdisorders, that relate to either serotonine or noradrenaline and effexor can work wonder for the one but not for the other?
Here are some sideeffect, that bother me. I startefd with 75 mg effexor and that was fine. After 3 months i had to add maprotilin 10-30 mg varying, as the would give an almost immediate relief from what i call "bad mood seizures". However i have recently had to increase the dose of effexor to 150 mg. I dont wan-t get into a more and more addiction, but ill return with further comments in a few months about wether i need more still then.
Another sideeffect, that sets in after some months, is not actual tirednes (SSRIs all made me intollerably tired), but a feeling of being energy-depleted. Like i have difficulty getting myself started. My body feel, like, too heavy to get mooving. But thats all i have to complain about.
I have to take effexor and maprotilin in the morning, because i do not sleep well on them. When i supplemented with mianserin i took minaserin before bed and slept like a log. I have tried replacing meprotillin with Mirtazepin (Remeron) and found that Remeron greatly improves my sleep (no more nightmares! Without Mirtazepin or mianserin i have several nightmares every night, awfull). Mirtazepin makes me very tired if taken in the morning (like all SSRIs do to me).
I also tried boosting effexor with Buspiron, but found buspiron, though an SSRI, does not seem to have an AD effect, It gave a nice soft feeling to the body and mind, though.
I've considered trying Anafranil or some other tricyclic alone or in combination with at first effexor and later maybe som other?
Can anyone relate to this with similar or other experiences?
Janus
poster:Janus
thread:13781
URL: http://www.dr-bob.org/babble/20010122/msgs/52603.html