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Is Pindolol+Busirone+ a neuroleptic safe?

Posted by AndrewB on January 5, 2001, at 5:58:19

Are there any drug interactions or other things to worry about when combining pindolol and buspirone with Zyprexa or amisulpride. Will buspirone's D2 antagonism blunt the action of these neuroleptics?

Ziprasidone's effectiveness and better side effect profile when compared to Zyprexa is speculated to be due to its action as a strong 5-HT1A agonist. When taken in low doses pindolol is a 5-HT1A presynaptic autoreceptor antagonist, thus complementing the moderate 5-HT1A postsynapitc receptor agonist action of buspirone.

Note: At low doses Zyprexa is a D2 autorector antagonist and 5-HT2 receptor antagonist, amisulpride is a D2/D3 autoreceptor antagonist, and Ziprasidone is a D2 autoreceptor antagonist, 5-HT2 antagonist and 5-HT1A agonist.

Thanks for any help,

AndrewB


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poster:AndrewB thread:50944
URL: http://www.dr-bob.org/babble/20001231/msgs/50944.html